Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas
نویسندگان
چکیده
منابع مشابه
Silencing of the p18 gene by promoter hypermethylation in the Reed-Sternberg cells in Hodgkin Lymphomas
p18 is a cyclin-dependent kinase inhibitor that interferes with the Rb-kinase activity of CDK6/CDK4. Disruption of p18 in mice impairs B-cell terminal differentiation and confers increased susceptibility to tumor development; however, alterations of p18 in human tumors have rarely been described. We used a tissue-microarray approach to analyze p18 expression in 316 Hodgkin Lymphomas (HL). Nearl...
متن کاملParaneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas.
Paraneoplastic neurological syndromes (PNSs) rarely associate with Hodgkin lymphoma (HL) and non-HLs (NHLs). Except for paraneoplastic cerebellar degeneration (PCD) in HL and dermato/ polymyositis in both HL and NHL, other PNSs are uncommon and have only been reported as isolated case reports or short series. There are several important differences in PNSs when occurring in association with HL ...
متن کاملRadioimmunotherapy of non-Hodgkin lymphomas.
Enthusiasm for the use of monoclonal antibodies, such as rituximab, has markedly changed the approach to patients with non-Hodgkin lymphomas (NHLs). Nevertheless, more effective therapies are needed. Radioimmunotherapy as a form of targeted radiation therapy may add significantly to our therapeutic options. Yttrium Y 90 ibritumomab tiuxetan, recently approved by the Food and Drug Administration...
متن کاملAlteration of SMRT tumor suppressor function in transformed non-Hodgkin lymphomas.
Indolent non-Hodgkin lymphomas are characterized by a prolonged phase that is typically followed by a clinical progression associated with an accelerated clinical course and short survival time. Previous studies have not identified a consistent cytogenetic or molecular abnormality associated with transformation. The development of a transformed phenotype, evolving from the original low-grade co...
متن کاملHodgkin Lymphoma and Anaplastic Variants of Non-Hodgkin Lymphoma
Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. Materials and Methods:...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2012
ISSN: 1479-5876
DOI: 10.1186/1479-5876-10-209